Royal Air Force Typhoon FGR4s have conducted a mission with French aircraft in a joint strike on an hidden munitions depot in Syrian territory used by the IS group, as stated by the UK Ministry of Defence.
The location, pinpointed through intelligence, was thought to be storing arms and explosives, the release indicated, and was located in mountainous terrain just to the north of the historic site of Palmyra in Syria's central region.
"Our aircraft utilized Paveway IV guided bombs to hit a series of approach shafts leading to the depot... preliminary assessments indicate the strike was effective," the MoD said.
There was no indication of any civilian impact in the attack on Saturday evening and all the aircraft made a safe return, the MoD added.
The Typhoon FGR4s were supported by a Voyager aerial refuelling aircraft.
IS - referred to as ISIS - imposed jihadist rule over parts of Syria and Iraq until 2019.
"This action demonstrates our UK leadership, and determination to work closely with our allies, to stamp out any re-emergence of the terrorist group and their dangerous and violent ideologies in the region," Britain's Defence Chief John Healey remarked.
British military aircraft have conducted patrols over Syria to "forestall any attempted resurgence" of the group subsequent to its routing at the battle of Baghuz in 2019, the ministry said.
"I must thank every member of our armed forces participating in this operation for their skill and their bravery," the Defence Secretary said. "They were part of a great many British personnel deployed over the holidays. This action, to eliminate dangerous terrorists who endanger our safety, shows how UK forces are prepared to act, throughout the year, ensuring Britain's security within its borders and influential overseas."
Last December, the American forces executed what it described as a "large-scale strike" on IS targets in Syria, after an assault resulted in the deaths of two American soldiers and a civilian linguist in Palmyra.
The UN says IS still boasts an estimated 5,000 to 7,000 combatants in both countries.